Drug Species Matrix Technique Anticoagulant Extraction
Volume
      Range Stable
Labeled I.S.
2-Deoxy-D-Glucose Human Plasma LC/MS/MS Heparin 0.1 mL 0.25-50 µg/mL Yes
2-Deoxy-D-Glucose Human Urine LC/MS/MS N/A 0.1 mL 1-200 µg/mL Yes
5-Amino Salicylic acid
N-Acetyl-5-ASA
Rabbit Plasma HPLC/UV Sodium Citrate 0.1 mL 50-5,000 ng/mL No
5-Amino Salicylic acid
N-Acetyl-5-ASA
Dog Plasma HPLC/UV Sodium Citrate 0.1 mL 50-5,000 ng/mL No
5-Amino Salicylic acid
N-Acetyl-5-ASA
Rabbit Plasma LC/MS/MS EDTA 0.025 mL 25-10,000 ng/mL
50-20,000 ng/mL
Yes
5-Amino Salicylic acid
N-Acetyl-5-ASA
Dog Plasma LC/MS/MS EDTA 0.025 mL 50-25,000 ng/mL
25-12,500 ng/mL
Yes
5-Fluorouracil Human Plasma LC/MS/MS Heparin 0.05 mL 5-2,500 ng/mL Yes
Acetaminophen Human Plasma HPLC/UV Heparin 0.1 mL 0.5-50 µg/mL No
Alprazolam
a-OH-Alprazolam
4-OH-Alprazolam
Human Plasma LC/MS/MS EDTA 0.050 mL 0.100-100 ng/mL Yes
Amitriptyline
Nortriptyline
Human Plasma LC/MS/MS Heparin 0.1 mL 0.25-250 ng/mL Yes
Anandamide Human Plasma LC/MS/MS Heparin 0.1 mL 0.1-5 ng/mL Yes
Anastrozole Human Plasma LC/MS/MS Heparin 0.1 mL 1-100 ng/mL Yes
Aplindore Human Plasma LC/MS/MS Heparin 0.5 mL 10-5,000 pg/mL Yes
Atorvastatin
p-hydroxyatorvastatin
o-hydroxyatrovastatin
Human Plasma LC/MS/MS EDTA or Heparin 0.05 mL 0.1-20 ng/mL Yes
Benzoic acid Minipig Plasma HPLC/UV EDTA 0.1 mL 50-2,000 ng/mL No
Benzoylecgonine Human Plasma LC/MS/MS Heparin 0.2 mL 25-10,000 ng/mL Yes
Benzyl alcohol Human Plasma HPLC/UV EDTA 0.1 mL 1-100 µg/mL No
Bromfenac Human Serum HPLC/UV N/A 0.25 mL 50-10,000 ng/mL No
Caffeine
1,7-dimethylxanthine
Human Plasma LC/MS/MS Heparin 0.1 mL 100-50,000 ng/mL
50-25,000 ng/mL
No
Caffeine
1,7-dimethylxanthine
Human Urine LC/MS/MS N/A 0.1 mL 500-25,000 ng/mL No
Calcipotriene Human Plasma LC/MS/MS Heparin 1.0 mL 10-2,000 pg/mL No
Campesterol
?-Sitosterol
Campestanol
Sitostanol
Human Plasma LC/MS/MS EDTA 0.1 mL 1,000-8,800 ng/mL
1,000-13,400 ng/mL
4-1,000 ng/mL
5-1,700 ng/mL
Yes
Carboxyethyphosphoramide mustard (CEPM) Human Plasma LC/MS/MS Heparin 0.05 mL 0.05-50 µg/mL Yes
Cephalothin Rat Plasma HPLC/UV Heparin 0.1 mL 0.5-50 µg/mL No
Cetylpyridinium Human Plasma LC/MS/MS Heparin 0.1 mL 1-200 ng/mL Yes
Chloroadenine Human Plasma LC/MS/MS Heparin 0.1 mL 1-500 ng/mL No
Cimetidine Human Plasma LC/MS/MS EDTA or Heparin 0.05 mL 5-5,000 ng/mL Yes
Citrulline Rat Plasma LC/MS/MS Heparin 0.1 mL 2-200 µg/mL No
Clindamycin
Clindamycin sulfoxide
Human Plasma LC/MS/MS EDTA 0.05 mL 50-20,000 pg/mL No
Clobetasol propionate Human Plasma LC/MS/MS EDTA 0.4 mL 20-10,000 pg/mL No
Clozapine Human Plasma LC/MS/MS Heparin 0.05 mL 0.2-200 ng/mL Yes
Cocaine
Norcocaine
Cocaethylene
Human Plasma LC/MS/MS Heparin 0.2 mL 25-10,000 ng/mL Yes
Cordycepin Human Whole Blood LC/MS/MS EDTA 0.05 mL 0.1-10 µg/mL Yes
Cortisol
6?-hydroxycortisol
Human Urine LC/MS/MS N/A 1.0 mL 5-250 ng/mL
50-2,500 ng/mL
No
Cytarabine Human Plasma LC/MS/MS EDTA 0.05 mL 2-500 ng/mL Yes
Daunorubicin
Daunorubicinol
Human Plasma LC/MS/MS EDTA 0.1 mL 1-1,000 ng/mL
0.2-200 ng/mL
Yes
Diclofenac Human Plasma LC/MS/MS Heparin 0.1 mL 1-1,000 ng/mL Yes
Digoxin Human Plasma LC/MS/MS Heparin 0.2 mL 0.1-10 ng/mL Yes
Docetaxel Human Plasma LC/MS/MS Heparin 0.25 mL 0.5-100 ng/mL Yes
Econazole Human Plasma HPLC/UV Heparin 1.0 mL 20-1,000 ng/mL
20-1,000 ng/mL
No
Econazole Human Plasma LC/MS/MS EDTA 0.2 mL 100-50,000 pg/mL No
Erlotinib Human Plasma LC/MS/MS Heparin 0.025 mL 10-10,000 ng/mL Yes
Ethinyl estradiol Human Plasma LC/MS/MS Heparin 0.5 mL 2-500 pg/mL Yes
Etoposide Human Plasma LC/MS/MS Heparin 0.02 mL 0.100-100 µg/mL Yes
Fentanyl Human Plasma LC/MS/MS Heparin 0.1 mL 50-20,000 pg/mL No
Fludarabine desphosphate Human Plasma LC/MS/MS Heparin 0.1 mL 0.5-500 ng/mL No
Ganaxolone Human Plasma LC/MS/MS EDTA 0.2 mL 5-1,500 ng/mL No
Gefitinib Human Plasma LC/MS/MS Heparin 0.05 mL 5-1,000 ng/mL Yes
Gentamicin Human Plasma LC/MS/MS Heparin 0.05 mL 2-5,000 ng/mL Yes
Gemcitabine Human Plasma LC/MS/MS Heparin 0.05 mL 10-10,000 ng/mL Yes
Gemfibrozil Human Plasma LC/MS/MS Heparin 0.025 mL 0.1-500 µg/mL Yes
Glimepiride Human Plasma LC/MS/MS Heparin 0.05 mL 2-2,000 ng/mL Yes
Glyburide Human Plasma LC/MS/MS EDTA or Heparin 0.1 mL 1-500 ng/mL No
Histamine
N-methylhistamine
Human Plasma LC/MS/MS EDTA 0.5 mL 0.2-50 ng/mL Yes
Histamine
N-methylhistamine
Human Urine LC/MS/MS N/A 0.05 mL 10-2,000 ng/mL
50-10,000 ng/mL
Yes
Ketoconazole Human Plasma LC/MS/MS EDTA 0.05 mL 5-5,000 ng/mL Yes
L-Arginine Human Plasma HPLC/UV Heparin 0.125 mL 1-250 µg/mL No
L-Methionine Human Plasma LC/MS/MS Heparin 0.1 mL 1-200 µg/mL Yes
Lamotrigine Human Plasma LC/MS/MS Heparin 0.025 mL 0.025-25 µg/mL Yes
Levofloxacin Human Plasma LC/MS/MS Heparin 0.025 mL 10-10,000 ng/mL Yes
Lidocaine Human Plasma LC/MS/MS Heparin 0.1 mL 0.2-100 ng/mL No
Lidocaine Human Plasma LC/MS/MS EDTA 0.1 mL 0.2-100 ng/mL Yes
Lidocaine
2,6 - dimethylaniline
Monoethylglycinexylidide
Glycinexylidide
Human Plasma LC/MS/MS EDTA or Heparin 0.1 mL 0.2-200 ng/mL

1-1,000 ng/mL
Yes
Lucanthone
Hycanthone
Human Plasma LC/MS/MS Heparin 0.05 mL 1-200 ng/mL Yes
Metformin Human Plasma LC/MS/MS Heparin 0.05 mL 10-2,000 ng/mL Yes
Methotrexate Human Plasma LC/MS/MS Heparin 0.05 mL 1-1,000 ng/mL Yes
Midazolam Human Plasma LC/MS/MS EDTA 0.1 mL 0.5-250 ng/mL No
Midazolam
1-hydroxymidazolam
Human Plasma LC/MS/MS EDTA 0.1 mL 0.5-100 ng/mL Yes
Mifepristone Human Plasma LC/MS/MS Heparin 0.05 mL 10-2,000 ng/mL Yes
Mitiglinide Human Plasma LC/MS/MS Heparin 0.1 mL 1-1,000 ng/mL No
Mitomycin Human Plasma LC/MS/MS EDTA 0.05 mL 10-5,000 ng/mL No
Morphine
Morphine-6-?-D-glucuronide
Human Plasma LC/MS/MS Heparin 0.1 mL 0.5-500 ng/mL Yes
N-acetylcysteine Dog Plasma LC/MS/MS EDTA 0.025 mL 1-1,000 µg/mL Yes
N-acetylcysteine Rabbit Plasma LC/MS/MS EDTA 0.025 mL 1-1,000 µg/mL Yes
Nabilone Human Plasma LC/MS/MS Heparin 0.5 mL 100-20,000 pg/mL No
Naloxone Human Plasma LC/MS/MS Heparin 0.25 mL 0.1-50 ng/mL No
Nalbuphine Human Plasma LC/MS/MS Heparin 0.25 mL 0.1-50 ng/mL No
Naproxen Human Plasma LC/MS/MS Heparin 0.025 mL 0.100-100 µg/mL Yes
Norethindrone Human Plasma LC/MS/MS Heparin 0.25 mL 20-10,000 pg/mL Yes
Norgestrel
17-deacetylnorgestimate
Human Plasma LC/MS/MS Heparin 0.25 mL 40-20,000 pg/mL
20-10,000 pg/mL
Yes
Ondansetron Human Plasma LC/MS/MS Heparin 0.05 mL 0.5-250 ng/mL Yes
Oxycodone Human Plasma LC/MS/MS EDTA or Heparin 0.1 mL 0.2-50 ng/mL Yes
Oxycodone
Oxymorphone
Noroxycodone
Human Plasma LC/MS/MS Heparin 0.5 mL 0.05-25 ng/mL Yes
Paclitaxel Human Plasma LC/MS/MS EDTA or Heparin 0.1 mL 0.5-200 ng/mL No
Prilocaine Human Plasma LC/MS/MS EDTA 0.05 mL 0.2-100 ng/mL No
Promethazine Human Plasma LC/MS/MS Heparin 0.1 mL 0.2-100 ng/mL No
Quetiapine Human Plasma LC/MS/MS EDTA or Heparin 0.05 mL 1-1,000 ng/mL Yes
Repaglinide Human Plasma LC/MS/MS EDTA 0.05 mL 0.1-100 ng/mL Yes
Riboflavin
Riboflavin 5-phosphate
Dog Plasma Fluorescence Heparin 0.05 mL 20-10,000 ng/mL
40-20,000 ng/mL
No
Riboflavin
Riboflavin 5-phosphate
Rat Plasma Fluorescence Heparin 0.05 mL 20-10,000 ng/mL
40-20,000 ng/mL
No
Rifampin
25-desacetylrifampin
Human Plasma LC/MS/MS EDTA 0.05 mL 0.1-20 µg/mL Yes
Riluzole Human Serum LC/MS/MS N/A 0.1 mL 1-500 ng/mL No
Risperidone
9- hydroxyrisperidone
Human Plasma LC/MS/MS Heparin 0.05 mL 0.1-100 ng/mL Yes
Rosuvastatin
n-desmethyl rosuvastatin
Human Plasma LC/MS/MS Heparin 0.1 mL 0.1-50 ng/mL Yes
Simvastatin
Simvastatin hydroxy acid
Human Plasma LC/MS/MS Heparin 0.25 mL 0.05-50 ng/mL Yes
Sorafenib Human Plasma LC/MS/MS EDTA 0.05 mL 10-10,000 ng/mL Yes
Sumatriptan Human Plasma LC/MS/MS Heparin 0.1 mL 1-200 ng/mL No
Tolbutamide Human Plasma LC/MS/MS EDTA 0.1 mL 0.1-20 µg/mL No
Tolbutamide
4-hydroxytolbutamide
Human Urine LC/MS/MS N/A 0.1 mL 0.1-20 µg/mL No
Trazodone Human Plasma LC/MS/MS Heparin 0.05 mL 0.2-200 ng/mL Yes
Tretinoin Human Plasma LC/MS/MS EDTA 0.2 mL 0.4-10 ng/mL Yes
Valerenic acid
Hydroxyvalerenic acid
Acetoxyvalerenic acid
Human Plasma LC/MS/MS Heparin 0.2 mL 1-500 ng/mL No
Vancomycin Human Plasma LC/MS/MS Heparin 0.02 mL 50-25,000 ng/mL No
Warfarin (R-) Human Plasma LC/MS/MS Heparin 0.025 mL 2-2,000 ng/mL Yes
Warfarin (S-) Human Plasma LC/MS/MS Heparin 0.025 mL 2-2,000 ng/mL Yes
Yohimbine Human Plasma LC/MS/MS EDTA 0.1 mL 0.1-50 ng/mL No
Zolpidem Human Plasma LC/MS/MS EDTA 0.05 mL 1-150 ng/mL Yes
Zolpidem Baboon Plasma LC/MS/MS EDTA 0.05 mL 1-1,000 ng/mL Yes